Risk of AdMs in TI patients with NDMM (n = 360). The risk of AdMs (SyMs + SPMs) was increased (SIR, 2.17; 95% CI, 1.51-3.02) compared to the general population. When we dissected the risk from SPMs to SyMs, we observed a significant excess risk of SyMs (SIR, 8.20; 95% CI, 4.68-13.31) but not of SPMs (SIR, 1.15; 95% CI, 0.69-1.79).