Box plot showing the median TTSA and 25th to 75th IQR for ESI groups 2 and 3 with ASH subsequent analgesic recommendation cutoff highlighted in red. Median TTSA was 72 minutes for ESI 2, and 78 minutes for ESI 3 (P = .486). IQR for TTSA in patients assigned an ESI of 2 was 55 to 147 minutes, whereas the IQR for patients who were assigned an ESI of 3 was 61 to 141 minutes. The 60-minute cutoff for TTSA as recommended by ASH is highlighted in red. Second analgesic administration within the recommended cutoff occurred in 39.1% and 23.7% of those assigned an ESI of 2 and 3, respectively.