CUX1 levels finely regulate HSC fate: low levels maintain stemness, whereas high levels drive differentiation. HSCs retain latent plasticity and can reacquire stemness when CUX1 is reduced. This process involves controlled derepression of EREs, which activates antiviral innate immune signaling to promote self-renewal. The figure was created with BioRender.com. Porteu F. (2025) https://app.biorender.com/illustrations/68a77f0aa4f8865f0afd098e.

CUX1 levels finely regulate HSC fate: low levels maintain stemness, whereas high levels drive differentiation. HSCs retain latent plasticity and can reacquire stemness when CUX1 is reduced. This process involves controlled derepression of EREs, which activates antiviral innate immune signaling to promote self-renewal. The figure was created with BioRender.com. Porteu F. (2025) https://app.biorender.com/illustrations/68a77f0aa4f8865f0afd098e.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal