Schematic representation of the role of N-glycosylation in the CDR of the immunoglobulin heavy chain in FL and Mann-type DLBCL. Of note, immunoglobulin light chain CDRs can also be glycosylated in these lymphomas. Mann-type DLBCL (upper right) shares the presence of a BCL2 translocation and/or an EZB-type mutational profile (middle panel) with conventional FL (upper left). Oligomannoses in the CDR of the surface immunoglobulin as part of the BCR bind to DC-SIGN expressed by macrophages or dendritic cells. This results in continuous BCR signaling via CD79a/b with activation of the downstream PI3K/AKT pathway. The difference between the generally indolent behavior of FL and Mann-type DLBCL, especially in comparison with other DLBCL of GCB type, warrants further studies. The figure was created, in part, with BioRender.com. Montes I. (2025) https://BioRender.com/r2fnrs7.

Schematic representation of the role of N-glycosylation in the CDR of the immunoglobulin heavy chain in FL and Mann-type DLBCL. Of note, immunoglobulin light chain CDRs can also be glycosylated in these lymphomas. Mann-type DLBCL (upper right) shares the presence of a BCL2 translocation and/or an EZB-type mutational profile (middle panel) with conventional FL (upper left). Oligomannoses in the CDR of the surface immunoglobulin as part of the BCR bind to DC-SIGN expressed by macrophages or dendritic cells. This results in continuous BCR signaling via CD79a/b with activation of the downstream PI3K/AKT pathway. The difference between the generally indolent behavior of FL and Mann-type DLBCL, especially in comparison with other DLBCL of GCB type, warrants further studies. The figure was created, in part, with BioRender.com. Montes I. (2025) https://BioRender.com/r2fnrs7.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal