Increasing statin intensity is associated with higher HRs for CHR in pegylated IFN-α2–treated patients with MPN. Forest plot showing HR for CHR according to statin treatment intensity among patients treated with IFN-α2. A dose-response relationship was observed, with moderate intensity statin use associated with an HR (95% CI) of 2.3 (1.3-4.1), P = .005 and high intensity statin use associated with an HR (95% CI) of 2.9 (1.4-5.8), P = .005. The multivariable-adjusted Cox regression was adjusted for age, sex, and smoking. W/o, without.