Longitudinal changes in patient-reported outcomes during the 5-week treatment phase and 6-month follow-up visits. Each panel depicts the within-subject mean change from baseline (posttreatment minus baseline) for each time point. Blue symbols represent the usual care-only group, whereas red symbols represent the acupressure plus usual care group. Negative values reflect improvement except in QoL. Blue boxes represent the group comparison at the fifth week time point between the 2 groups. ∗P < .001; ∗∗P < .01; ∗∗∗P < .05 (compared to baseline). BPI, Brief Pain Inventory; PedsQL, Pediatric QoL Inventory.