NRM of MCR reclassification of clinical responders and nonresponders. The 6-month cumulative incidence of NRM by clinical response reclassified by MCR criteria. (A) Clinical responders reclassified by MCR. Left: training set MAGIC composite responders: 5.9% (95% CI, 4.1%-8.0%), MAGIC composite nonresponders: 30.7% (CI, 22.0%-39.8%). Right: validation set MAGIC composite responders: 6.8% (95% CI, 3.7%-11.2%), MAGIC composite nonresponders: 34.3% (95% CI, 16.9%-52.6%). (B) Clinical nonresponders reclassified by MCR. Left: training set MAGIC composite responders: 5.0% (95% CI, 0.9%-15.0%), MAGIC composite nonresponders: 46.7% (95% CI, 37.6%-55.3%). Right: validation set MAGIC composite responders: 7.6% (95% CI, 1.3%-22.0%), MAGIC composite nonresponders: 50.7% (95% CI, 37.8%-62.2%). Pie charts depict percentage of responders/nonresponders.