Weighted correlation network analysis identifies functional protein modules with clinical relevance. (A) Bubble plot displaying 24 protein clusters (functional modules, ME1-24). Modules highly correlated with clinical features, molecular characteristics, and proteomic subtypes are colored. The ME22 is highlighted in red font. (B) Kaplan-Meier curves for OS (upper panel) and EFS (lower panel) of patients with AML stratified by protein abundance in ME22, with the most obvious prognostic discrimination used as the cutoff value. (C) Heat map showing the relative abundance of proteins derived from the ME22 module (left panel). Univariate Cox regression analysis indicating the prognostic value of each protein (right panel). The middle red points indicate the hazard ratio for each protein, and end points represent lower or upper 95% confidence intervals (CIs). (D) Pathway enrichment analysis of ME22-derived proteins between the combination of S2, S3, and S7 and patients with residual AML using BP, CC, and MF in GO, and Kyoto encyclopedia of genes and genomes (KEGG). BP, biological process; CC, cellular component; MF, molecular function.