Figure 1.
Patients with FL exhibit significant changes in PB immune subsets at baseline. Spectral flow cytometry was used to assess PB immune subsets at study baseline (n = 34) compared with age-matched healthy donors (n = 12). Proportions of (A) CD25+CD127−CD4+ Tregs, (B) PD-1+ Tregs, (C) HLA-DR Tregs, (D) CD4 naïve (CCR7+CD45RA+), TCM (CCR7+CD45RA−), TEM (CCR7−CD45RA−), and TEMRA (CCR7−CD45RA+) T cells, expression of immune checkpoints across (E) CD4 and (F) CD8 T cells, (G) total NK cells, and (H) TIM3 expression on NK memory subsets. An unpaired t test with correction for multiple comparisons was performed for panels E-F,H. A Mann-Whitney U test was performed for all other graphs. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001. TCM, Central Memory T cells; TEM, effector memory T cells; TEMRA, terminally differentiated T cells expressing CD45RA.

Patients with FL exhibit significant changes in PB immune subsets at baseline. Spectral flow cytometry was used to assess PB immune subsets at study baseline (n = 34) compared with age-matched healthy donors (n = 12). Proportions of (A) CD25+CD127−CD4+ Tregs, (B) PD-1+ Tregs, (C) HLA-DR Tregs, (D) CD4 naïve (CCR7+CD45RA+), TCM (CCR7+CD45RA−), TEM (CCR7−CD45RA−), and TEMRA (CCR7−CD45RA+) T cells, expression of immune checkpoints across (E) CD4 and (F) CD8 T cells, (G) total NK cells, and (H) TIM3 expression on NK memory subsets. An unpaired t test with correction for multiple comparisons was performed for panels E-F,H. A Mann-Whitney U test was performed for all other graphs. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001. TCM, Central Memory T cells; TEM, effector memory T cells; TEMRA, terminally differentiated T cells expressing CD45RA.

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