Hematologic response at 12 months after splenectomy among patients with ITP, stratified by TPO-RA use. The left panel shows hematologic response rates, CR, PR, and NR, at 12 months after splenectomy, stratified by postsplenectomy TPO-RA use. CR was the most common outcome in both groups but occurred more frequently among patients who did not receive TPO-RAs. PR and NR were more evenly distributed across groups. The right panel shows the proportion of patients who required additional ITP-directed treatment following splenectomy; 38% achieved CR with additional ITP therapies other than TPO-RAs. CR, complete response; NR, no response; PR, partial response.