Platelet count trajectories following splenectomy in patients with ITP, stratified by postsplenectomy TPO-RA use. Box plots illustrate platelet counts (×109/L) at predefined time points: baseline (before splenectomy) and 1 week, 4 weeks, 3 months, 6 months, and 12 months after splenectomy. Although both groups experienced a rapid rise in platelet counts during the first week, a broader range and higher peak counts were observed in the non–TPO-RA group. Over time, platelet counts declined and stabilized in both groups, with overlapping medians from 3 months onward. The use of TPO-RAs after splenectomy was more common among patients with lower or less sustained platelet responses, which is reflected in the slightly lower median counts in this group beyond the initial postoperative period.
