Cumulative incidence of thrombosis following splenectomy in patients with ITP, stratified by TPO-RA use. (A) The 10-year cumulative incidence of thrombosis after splenectomy, which was numerically higher among patients who received postsplenectomy TPO-RAs (57%) than those who did not (33%; P = .06). The divergence between groups emerged early, primarily within the first year. (B) The 1-year cumulative incidence of thrombosis after splenectomy, again showing a numerically higher incidence in the TPO-RA group (25% vs 15%; P = .35). Although neither comparison reached statistical significance, likely because of sample size and censoring imbalance, the data suggest a potential trend toward increased thrombotic risk with TPO-RA use in the early postsplenectomy period.