CAR T-cell responses separated by BMI. (A) Hypothetical model for relationship between BMI and CAR T-cell therapy outcomes. (B) A Cox proportional hazards model was used to evaluate the association between BMI and PFS. A cubic spline model with 3 degrees of freedom was applied to assess for the presence of a nonlinear relationship between BMI and PFS. The observed HR across the BMI range with 95% CI is shown. (C) Best objective response after CAR T-cell therapy shown for the normal weight (BMI < 25.0 kg/m²), overweight (BMI 25.0-29.9 kg/m²), and obese (BMI ≥ 30.0 kg/m²) groups. PFS (D) and OS (E) for the normal weight, overweight, and obese groups. CR, complete response; HR, hazard ratio; ORR, overall response rate; PR, partial response; VGPR, very good partial response.