Figure 2.
RBC deformability measured by osmotic gradient ektacytometry in HX. (A) Representative osmotic gradient ektacytometry curve of a patient with PIEZO1-HX (blue) and a patient with KCNN4-HX (red). (B) Median values of Omin, representing surface area-to-volume ratio, of 12 patients with PIEZO1-HX, 3 patients with KCNN4-HX, and 9 HCs. (C) Median values of EImax, representing the total surface area and maximal deformability of the RBC population. (D) Median values of Ohyper, representing the hydration of RBCs. (E) Median values of AUC. Error bars represent IQR. ∗∗∗∗P < .0001; ∗∗P < .01; ∗P < .05. Square symbols indicate splenectomized patients.

RBC deformability measured by osmotic gradient ektacytometry in HX. (A) Representative osmotic gradient ektacytometry curve of a patient with PIEZO1-HX (blue) and a patient with KCNN4-HX (red). (B) Median values of Omin, representing surface area-to-volume ratio, of 12 patients with PIEZO1-HX, 3 patients with KCNN4-HX, and 9 HCs. (C) Median values of EImax, representing the total surface area and maximal deformability of the RBC population. (D) Median values of Ohyper, representing the hydration of RBCs. (E) Median values of AUC. Error bars represent IQR. ∗∗∗∗P < .0001; ∗∗P < .01; ∗P < .05. Square symbols indicate splenectomized patients.

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