Biological diagnosis strategy for B-CLPDs. Dominant diagnoses appear in the colored boxes in the upper part of the diagram. These 10 colored boxes have been numbered to facilitate their identification in “Results.” Nearly half of the cases are identified with certainty by flow cytometry alone. Only 3.9% of the cases are directed in a group with no dominant subtype. The lower part of the diagram indicates additional tests for either confirmation of the diagnosis proposed by cytometry or discrimination of the other subtypes. CD, cluster of differentiation; CLL, chronic lymphocytic leukemia/lymphocytic lymphoma; FL, follicular lymphoma; HCL, hairy cell leukemia; LPL, lymphoplasmacytic lymphoma; MCL, mantle cell lymphoma; MZL, marginal zone lymphoma; NA, not applicable; NDS, no dominant subtype; PPV, positive predictive value; Q, quantile (in instance percentile). ∗The MYD88 L265P mutation can also be detected in rare cases of MZL and CLL.