Figure 3.
Carbon labeling of the PPP metabolites in patients with HK or PK deficiency. Purified RBCs from 10 controls; 2 patients with HK deficiency (HKD1-2) (A) and 3 patients with PK deficiency (PKD1-3) (B) were incubated with 13C6-glucose. The incorporation of the labeled carbon atoms in downstream PPP metabolites was determined over time by quantifying the concentrations of carbon-labeled metabolites with LC-HRMS. Data points with error bars indicate mean and standard deviation.

Carbon labeling of the PPP metabolites in patients with HK or PK deficiency. Purified RBCs from 10 controls; 2 patients with HK deficiency (HKD1-2) (A) and 3 patients with PK deficiency (PKD1-3) (B) were incubated with 13C6-glucose. The incorporation of the labeled carbon atoms in downstream PPP metabolites was determined over time by quantifying the concentrations of carbon-labeled metabolites with LC-HRMS. Data points with error bars indicate mean and standard deviation.

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