Figure 1.
SAR leads to decrease in AML involvement in a patient-derived xenograft model. NSG mice were inoculated with patient-derived AML cells (n = 10) 1 day after sublethal irradiation, 300 cGy. After detection of human engraftment in the peripheral blood, the animals were treated with SAR or isotype control. (A) AML blasts from bone marrow aspirate samples were stained with anti-hCD123 phycoerythrin (PE) and anti-hCD3 allophycocyanin (APC). Right depicting a representative plot. (B) Patient-derived xenograft schema. (C) Summary of analyzed bone marrow. Samples collected from NSG mice were stained with anti-hCD45 prussian blue (PB) and -hCD123 PE. Mean with standard deviation shown. Statistical analysis was performed by unpaired t test using GraphPad Prism 10.0 (GraphPad Software Inc). hCD45, human CD45.

SAR leads to decrease in AML involvement in a patient-derived xenograft model. NSG mice were inoculated with patient-derived AML cells (n = 10) 1 day after sublethal irradiation, 300 cGy. After detection of human engraftment in the peripheral blood, the animals were treated with SAR or isotype control. (A) AML blasts from bone marrow aspirate samples were stained with anti-hCD123 phycoerythrin (PE) and anti-hCD3 allophycocyanin (APC). Right depicting a representative plot. (B) Patient-derived xenograft schema. (C) Summary of analyzed bone marrow. Samples collected from NSG mice were stained with anti-hCD45 prussian blue (PB) and -hCD123 PE. Mean with standard deviation shown. Statistical analysis was performed by unpaired t test using GraphPad Prism 10.0 (GraphPad Software Inc). hCD45, human CD45.

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