Figure 1.
P-selectin binding affinity was higher for inclacumab than for crizanlizumab. P-selectin binding affinity of crizanlizumab (A) and inclacumab estimated using Biacore SPR assay (B). (C) Average kinetic parameters calculated from 4 measurements (2 independent experiments) are shown. ka, association constant; kd, dissociation constant; KD, equilibrium dissociation constant (KD = kd/ka); SD, standard deviation. ∗P ≤ .05.

P-selectin binding affinity was higher for inclacumab than for crizanlizumab. P-selectin binding affinity of crizanlizumab (A) and inclacumab estimated using Biacore SPR assay (B). (C) Average kinetic parameters calculated from 4 measurements (2 independent experiments) are shown. ka, association constant; kd, dissociation constant; KD, equilibrium dissociation constant (KD = kd/ka); SD, standard deviation. ∗P ≤ .05.

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