ATC treatment of RAG-1 KO mice leads to acquired mutations in genes important for cancer. (A) Acquired C>G mutations involving genes important for cancer in ATC-treated RAG-1 KO leukemia. (B) Most common Tier 1 C>G transversions (identified from WES data of RAG-1 KO ATC B-lineage leukemias), normalized for gene length (see “Materials and methods”). (C) C>G mutation at mutational hot spots in human B-ALL. Murine Trp53 R270 is equivalent to human TP53 R273 and murine Ptpn11 S506 is equivalent to human PTPN11 S502.
Figure 5.

ATC treatment of RAG-1 KO mice leads to acquired mutations in genes important for cancer. (A) Acquired C>G mutations involving genes important for cancer in ATC-treated RAG-1 KO leukemia. (B) Most common Tier 1 C>G transversions (identified from WES data of RAG-1 KO ATC B-lineage leukemias), normalized for gene length (see “Materials and methods”). (C) C>G mutation at mutational hot spots in human B-ALL. Murine Trp53 R270 is equivalent to human TP53 R273 and murine Ptpn11 S506 is equivalent to human PTPN11 S502.

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