Figure 2. BCPs in RAG-1 KO BM are... | American Society of Hematology

$BCPs in RAG-1 KO BM are potential targets for ATC-induced leukemic transformation. (A) Flow cytometry analysis of untreated C57BL/6 and untreated RAG-1 KO BM; #1, #2, and #3 represent 3 discrete populations of CD19+B220+ cells. (B) Schematic of BM B-cell differentiation based on surface markers and IgH VDJ recombination. (C) Hardy fraction staining of untreated RAG-1 KO and WT mouse. Red box indicates B220+CD43– progenitors missing in RAG-1 KO mouse. RAG-1 KO mouse shows accumulation of Hardy fraction C and decreased C' compared WT BM. CLP, common lymphocyte progenitor; GL, germ line; IgH, immunoglobulin heavy chain.$

Figure 2.

BCPs in RAG-1 KO BM are potential targets for ATC-induced leukemic transformation. (A) Flow cytometry analysis of untreated C57BL/6 and untreated RAG-1 KO BM; #1, #2, and #3 represent 3 discrete populations of CD19⁺B220⁺ cells. (B) Schematic of BM B-cell differentiation based on surface markers and IgH VDJ recombination. (C) Hardy fraction staining of untreated RAG-1 KO and WT mouse. Red box indicates B220⁺CD43^– progenitors missing in RAG-1 KO mouse. RAG-1 KO mouse shows accumulation of Hardy fraction C and decreased C' compared WT BM. CLP, common lymphocyte progenitor; GL, germ line; IgH, immunoglobulin heavy chain.

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