ATC treatment leads to B-lineage ALL in RAG-1 KO mice. (A) Survival of RAG-1 KO mice treated with ATC or phosphate-buffered saline (PBS). Log-rank (Mantel-Cox) P < .0001 for ATC-treated mice vs PBS treated mice. Days represent time postinitiation of ATC treatment. (B) Flow cytometry of BM and spleen from an untreated RAG-1 KO mouse and a moribund ATC-treated RAG-1 KO mouse (8664) stained for CD19, B220, Mac1, Gr1, CD71, and Ter119.
Figure 1.

ATC treatment leads to B-lineage ALL in RAG-1 KO mice. (A) Survival of RAG-1 KO mice treated with ATC or phosphate-buffered saline (PBS). Log-rank (Mantel-Cox) P < .0001 for ATC-treated mice vs PBS treated mice. Days represent time postinitiation of ATC treatment. (B) Flow cytometry of BM and spleen from an untreated RAG-1 KO mouse and a moribund ATC-treated RAG-1 KO mouse (8664) stained for CD19, B220, Mac1, Gr1, CD71, and Ter119.

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