Figure 1. Distinct patterns of IR in the... | American Society of Hematology

$Distinct patterns of IR in the bone marrow vs blood after transplantation highlighted by greater NK cell abundance in the marrow after transplant. (A) Swimmer plot summarizing longitudinal samples analyzed across the 33-patient cohort (clinical details in supplemental Table 1): n = 110 marrow samples; n = 115 blood samples. (B) Tracking innate and adaptive lymphocytes in the bone marrow and blood longitudinally as a frequency out of lymphocytes. Data visualized by locally weighted scatterplot smoothing curve (quantification of lymphocyte subsets as a fraction of CD45+ cells is included in supplemental Figure 2A; absolute counts for PB are included in supplemental Figure 2B). (C) Early NK cell expansion and subsequent persistence in the bone marrow. Wilcoxon signed-rank test performed at each time point in both the marrow and PB comparing CD3 T cells out of lymphocytes with CD56 NK cells out of lymphocytes (supplemental Table 4). (D) T cell to NK cell ratio on natural log scale for each patient, stratified by compartment. Wilcoxon signed-rank test performed at each time point comparing marrow and blood T cell to NK cell ratio (supplemental Table 5). pre-tx, pretransplant.$

Figure 1.

Distinct patterns of IR in the bone marrow vs blood after transplantation highlighted by greater NK cell abundance in the marrow after transplant. (A) Swimmer plot summarizing longitudinal samples analyzed across the 33-patient cohort (clinical details in supplemental Table 1): n = 110 marrow samples; n = 115 blood samples. (B) Tracking innate and adaptive lymphocytes in the bone marrow and blood longitudinally as a frequency out of lymphocytes. Data visualized by locally weighted scatterplot smoothing curve (quantification of lymphocyte subsets as a fraction of CD45⁺ cells is included in supplemental Figure 2A; absolute counts for PB are included in supplemental Figure 2B). (C) Early NK cell expansion and subsequent persistence in the bone marrow. Wilcoxon signed-rank test performed at each time point in both the marrow and PB comparing CD3 T cells out of lymphocytes with CD56 NK cells out of lymphocytes (supplemental Table 4). (D) T cell to NK cell ratio on natural log scale for each patient, stratified by compartment. Wilcoxon signed-rank test performed at each time point comparing marrow and blood T cell to NK cell ratio (supplemental Table 5). pre-tx, pretransplant.

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