Elevated expression of IL-1 genes in the synovium of knee joints of F8em1−/− mice after needle injury. (A) KEGG pathway analysis of IL-1–like cytokine receptor gene expression in the F8em1−/− mice synovium after a knee injury. Quantitative reverse transcription polymerase chain reaction of knee synovium expression of F8em1−/− mice during the time after needle injury for IL-1 family members Il1b, Il1rl1, and Il33 (B); and the proinflammatory cytokines Il6 and Tnf (C). Data are presented as mean ± SEM from using synovium pooled from 3 to 4 F8em1−/− or WT mice per time point and from duplicate experiments. RQ, relative quantification.
Figure 5.

Elevated expression of IL-1 genes in the synovium of knee joints of F8em1−/− mice after needle injury. (A) KEGG pathway analysis of IL-1–like cytokine receptor gene expression in the F8em1−/− mice synovium after a knee injury. Quantitative reverse transcription polymerase chain reaction of knee synovium expression of F8em1−/− mice during the time after needle injury for IL-1 family members Il1b, Il1rl1, and Il33 (B); and the proinflammatory cytokines Il6 and Tnf (C). Data are presented as mean ± SEM from using synovium pooled from 3 to 4 F8em1−/− or WT mice per time point and from duplicate experiments. RQ, relative quantification.

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