Inflammatory gene expression in the synovium of knee joints of F8em1−/− mice after needle injury-induced HA. (A) Heat map of NanoString nCounter Solver of immunology gene expression in synovium from F8em1−/− mice on days 2, 7, and 14, and day 28 after needle injury compared with uninjured F8em1−/− synovial tissue. Gene clusters 1 through 5 were identified. (B) PCA of gene expression in the synovium of uninjured (day 0) and 2, 7, 14, and 28 days after needle injury of F8em1−/− and WT mice after needle injury. GO analysis of classifications of compartmentalized DEGs attributed to PCA1 (C) and PCA2 (D). The synovium from knee joints of the hind legs of 3 to 7 uninjured or needle-damaged F8em1−/− and WT mice was recovered at each time point and pooled for RNA isolation. adj, adjusted; GO, gene ontology.
Figure 4.

Inflammatory gene expression in the synovium of knee joints of F8em1−/− mice after needle injury-induced HA. (A) Heat map of NanoString nCounter Solver of immunology gene expression in synovium from F8em1−/− mice on days 2, 7, and 14, and day 28 after needle injury compared with uninjured F8em1−/− synovial tissue. Gene clusters 1 through 5 were identified. (B) PCA of gene expression in the synovium of uninjured (day 0) and 2, 7, 14, and 28 days after needle injury of F8em1−/− and WT mice after needle injury. GO analysis of classifications of compartmentalized DEGs attributed to PCA1 (C) and PCA2 (D). The synovium from knee joints of the hind legs of 3 to 7 uninjured or needle-damaged F8em1−/− and WT mice was recovered at each time point and pooled for RNA isolation. adj, adjusted; GO, gene ontology.

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