Pharmacokinetic simulations of the post-DDAVP FVIII pharmacokinetic profile in function of the F8 genotype (non-null vs null variant). Based on our final population model from GIDEHAC data analyses, Monte Carlo simulations were developed to generate a virtual population of 1000 patients with predicted PK parameters of VWF:Ag and FVIII:C after administration of 0.3 μg/kg DDAVP. Predicted PK parameters were then determined separately for non-null F8 variants and null F8 variants.
Figure 6.

Pharmacokinetic simulations of the post-DDAVP FVIII pharmacokinetic profile in function of the F8 genotype (non-null vs null variant). Based on our final population model from GIDEHAC data analyses, Monte Carlo simulations were developed to generate a virtual population of 1000 patients with predicted PK parameters of VWF:Ag and FVIII:C after administration of 0.3 μg/kg DDAVP. Predicted PK parameters were then determined separately for non-null F8 variants and null F8 variants.

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