Evaluation and validation of the final model for the post-DDAVP PK of FVIII and VWF. (A) Goodness-of-fit plots for the VWF and FVIII PK. The goodness-of-fit plots were used for the population-based model of VWF:Ag (left) and FVIII:C (right) PK. Observed vs population predictions (upper) and observed FVIII:C levels vs individual predictions (mode) (lower); the gray line corresponds to the identity line, and the red line to the regression line. (B) Visual predictive check plots. Blue points represent VWF:Ag and FVIII:C measurements (observed values in patients); pink bands represent the prediction intervals of the model for the 5th, 50th, and 95th percentiles of 1000 simulations, respectively.
Figure 4.

Evaluation and validation of the final model for the post-DDAVP PK of FVIII and VWF. (A) Goodness-of-fit plots for the VWF and FVIII PK. The goodness-of-fit plots were used for the population-based model of VWF:Ag (left) and FVIII:C (right) PK. Observed vs population predictions (upper) and observed FVIII:C levels vs individual predictions (mode) (lower); the gray line corresponds to the identity line, and the red line to the regression line. (B) Visual predictive check plots. Blue points represent VWF:Ag and FVIII:C measurements (observed values in patients); pink bands represent the prediction intervals of the model for the 5th, 50th, and 95th percentiles of 1000 simulations, respectively.

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