Structure of the post-DDAVP FVIII and VWF pharmacokinetic model.$VVWF$ and $VFVIII$ represent the central volume of distribution of VWF and FVIII; $KsynthVWF$ and $KsynthFVIII$ represent the zero-order synthesis constant of VWF and FVIII; $ClVWF$ and $ClVWF$ represent the first-order elimination rate of VWF and FVIII; $Imax$ represents the inhibitory effect of VWF:Ag on FVIII clearance (⁠$ClFVIII)$⁠; $ClFVIII−Baseline$ represents the FVIII clearance to the baseline level.