Tornado diagram of the 10 variables with the greatest influence on cost-effectiveness for the United Kingdom health care model. The bars in red indicate an increase in the value, while the blue bars indicate a decrease in the value of the given variable, and the vertical dash line is the point where delayed HSCT becomes cost-effective. None of the changes in the input variable were able to make delayed HSCT more likely cost-effective compared with upfront HSCT (ie, the INMB does not become <$0). FLT3i. FLT3 inhibitor.