ctDNA metrics stratified by IPI score and LDH levels. Box plots depict the distribution of cfDNA concentration (nanograms per milliliter), ctDNA genomic equivalents (hGEs per milliliter), and ctDNA VAF (%) across the 2 clinical stratifications: IPI scores 0 to 3 vs 4 to 5 (A) and normal vs elevated LDH levels (B). Significant associations are indicated by asterisk. ∗PU test < 0.05, ∗∗PU test < 0.01. ns, not significant.
Figure 5.

ctDNA metrics stratified by IPI score and LDH levels. Box plots depict the distribution of cfDNA concentration (nanograms per milliliter), ctDNA genomic equivalents (hGEs per milliliter), and ctDNA VAF (%) across the 2 clinical stratifications: IPI scores 0 to 3 vs 4 to 5 (A) and normal vs elevated LDH levels (B). Significant associations are indicated by asterisk. ∗PU test < 0.05, ∗∗PU test < 0.01. ns, not significant.

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