Longitudinal monitoring of ctDNA levels, cfDNA concentration, and PET-CT TMTV. The panels represent each of the 14 patients, tracking ctDNA levels (hGEs per milliliter plasma; red), cfDNA concentration (nanograms per milliliter plasma; yellow; dashed), and TMTV (cubic centimeter; green) across multiple time points, including baseline, early treatment cycles for blood sampling (C1D8, C1D15, C2D1, and C2D15), interim, EOT, or later time points. Treatment beyond the first-line is indicated in parentheses after the time point, whereas time points during first-line treatment are presented without parentheses. Short curve bars indicate individual samplings. Three patients (patients 1106, 1182, and 1315) lacked ctDNA variants, meaning they had no measurable hGE. First-line interim and EOT PET-CT response, if available, and selected additional scans are depicted with color-coded circles at the top of each panel. Asterisk (∗) in patient 1127 (PMBCL) represents Deauville score 4 but clinically assessed to be in complete remission; double asterisks (∗∗) in patient 1182, Deauville score 4 after consolidative radiation. C, cycle; FU, follow-up; L, treatment line; N/A, not applicable.