Survival and PTR of biotinylated platelets without and during inflammation. (A,D) Percentage of biotinylated platelets in circulation. (B,E) Percentage of biotinylated platelets related to the 10-minute measurement after transfusion. (C,F) Percentage of biotinylated platelets related to the 1-hour measurement after transfusion. The line plot displays the mean and standard deviation of recovery or PTR over time. Statistical comparisons were performed at each time point using an unpaired t test, alongside a 2-way repeated measures ANOVA to assess changes over time and between conditions. Significance levels are indicated as follows: ∗P < .05; ∗∗P < .01; ∗∗P < .001; ∗∗∗∗P < .0001; NS, not statistically significant.