Somatic mutation VAF in CHIP genes over time. Clone growth over time in relation to the TCL1A genotype in the following CHIP genes: TET2 (A), SF3B1 (B), ASXL1 (C), SRSF2 (D), and DNMT3A (E). (A-E) Every patient is shown with a different color, and their FPD ID is depicted by the number. Shapes represent TCL1A genotype, T/T are squares, G/T are triangles, and G/G are circles. All VAFs are from bone marrow NGS and ES results.