Characterization of TCL1A SNP rs2887399 in patients with P/LP RUNX1 variants. (A) TCL1A SNP rs2887399 genotypes in P/LP RUNX1 patients and wild-type RUNX1 family controls. (B) Presence of HM in P/LP RUNX1 patients grouped by TCL1A SNP rs2887399 genotypes; there is no significant difference between the genotypes (exact test). (C) Somatic mutations in FPD patients diagnosed with HM grouped by TCL1A SNP rs2887399 genotypes. All data were obtained from bone marrow NGS and ES, except for those denoted by the asterisk, in which sequencing was done on peripheral blood. One-way analysis of variance showed no impact of the SNP on age of HM dx (P = .61).