Vk^∗MYC:Wwox KO PBTs display recurrent focal and large copy number alterations. (A) Heat map illustrating copy number abnormalities in BM PCs and Vk^∗MYC:Wwox KO PBPs. The y-axis represents individual samples, whereas the x-axis displays individual chromosomes, separated by solid lines. Color coding indicates copy number losses or gains at various chromosomal loci, with blue representing copy number loss and red indicating copy number gain. The intensity of the colors reflects the magnitude of the copy number alterations. (B) Scatter plots from Vk^∗MYC:Wwox KO-PBT samples illustrate widespread and pronounced copy number alterations across all samples. Focal and large copy number alterations are represented by red markers; those above zero indicate copy number gains, whereas markers below zero signify copy number losses. The names of the genes affected by specific copy number alterations are displayed near the corresponding alterations, with red indicating copy number gains and blue indicating copy number losses for the respective genes.