Responders to pirfenidone have qCT metrics in the upper lobes that are consistent with healthier lungs. This figure presents qCT metrics for the upper lobes of 23 patients, divided into 9 responders and 14 nonresponders. (A) Percentage of normal lung. (B) Percentage of air trapping. (C) Mean Jacobian. (D) Variance of Jacobian. (E) Representative qCT coronal cut of responder. (F) Representative qCT coronal cut of nonresponder. Orange triangles represent the right upper lobe; blue dots represent the left upper lobe; red squares indicate the mean values; horizontal lines show the median values, with the IQR represented by the corresponding box. All qCT metrics show statistically significant differences between responders and nonresponders. The P values, calculated using the Wilcoxon rank-sum test, are displayed per panel.