YX0798 shows oral bioavailability in rats. (A) YX0798 is metabolically stable in mouse, rat, and human as determined by an in vitro liver microsome stability assay. (B) YX0798 has high cell permeability. (C) YX0798 has good kinetic solubility in acidic FaSSGF. The beta-blocker atenolol was used as a control. (D) YX0798 showed oral bioavailability in rats. (E) YX0798 caused weak inhibition on hERG activity at 10 μM. CL_hep, hepatic clearance; CL_int, intrinsic clearance; FaSSGF, fasted-state simulated gastric fluid; FaSSIF, fasted-state simulated intestinal fluid; hERG, human ether-a-go-go related gene; PO, per os (by mouth).