The ferroptosis inhibitor FER-1 mitigates lipid peroxidation and boosts PTR. Storage of murine RBCs for 6 or 10 days in the presence of the ferroptosis inhibitor FER-1 or antioxidants (vitamin E) and Lands cycle-fueling l-carnitine significantly boosted PTR (A), an effect ablated by combined storage in the presence of the covalent GPX4 inhibitor ML210 (B). These effects were accompanied by consistent mitigation of lipid peroxidation by FER-1 and vitamin E +l-carnitine (C), and exacerbation of lipid peroxidation upon GPX4 inhibition (D; heat map of the top 50 by LDA by time and intervention). (E-H) Highlights of 8-iso-prostaglandin F2α, 5-HETE, and leukotriene B4.
Figure 7.

The ferroptosis inhibitor FER-1 mitigates lipid peroxidation and boosts PTR. Storage of murine RBCs for 6 or 10 days in the presence of the ferroptosis inhibitor FER-1 or antioxidants (vitamin E) and Lands cycle-fueling l-carnitine significantly boosted PTR (A), an effect ablated by combined storage in the presence of the covalent GPX4 inhibitor ML210 (B). These effects were accompanied by consistent mitigation of lipid peroxidation by FER-1 and vitamin E +l-carnitine (C), and exacerbation of lipid peroxidation upon GPX4 inhibition (D; heat map of the top 50 by LDA by time and intervention). (E-H) Highlights of 8-iso-prostaglandin F2α, 5-HETE, and leukotriene B4.

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