![Genetic polymorphisms in the region coding for GPX4 in 13 091 blood donors from the REDS RBC Omics. (A) Minor allele frequency for the most common SNPs in the region coding for GPX4 in 13 091 blood donors enrolled in REDS RBC Omics, and their association (–log10[P value]) to osmotic, oxidative, and storage hemolysis at storage day 42 (B). (C-D) Breakdown by demographics (sex, age, body mass index, ethnicity) for the top 2 common SNPs highlights the prevalence of these traits in female donors with higher body mass index and of African descent. (E-H) Breakdown of values for osmotic, oxidative, oxidized/reduced glutathione ratios (GSSG/GSH), and lactate levels as a function of rs73507255 (missense) SNP allele. (I) LDA of metabolite measurements in REDS index donors (n = 13 091) as a function of GPX4 rs73507255 alleles, unadjusted (x-axis), or adjusted by storage additive, donor sex, age, and body mass index. BMI, body mass index.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodrci/1/3/10.1016_j.brci.2025.100020/1/brci_rci-2025-000146-gr2.jpeg?Expires=1763155557&Signature=5HOXqQZyuxTQdnu1W~VOQFd9eYZSFyUtMOsvMbFNxTwmBQa~lGCaXSknyWriCQ-165o75Hq3V8lUAGUsr8vhNBGxQ4UR-wpDZOOcYU8ob0h5tNIlsrWYLTy5n-IOyzfX1-haczZxxWQjuNokHaO~6Ft8tybCLJYtw1tT5wmnEUIdwAlHhpw9G8evkLB1xl90Ix0H~6BzaU-G1oPtkmcJUyfcMTFsGxRUJym6bNleswVGKTdCz5aTtccFt4jhnpsoQozK-mH71ZAIZM25oDH5i2OU788~QmoqPJt6qZG5CA9Guvh0frYa8WyWkgq4MFoCgio8M2gkBTuKp1bEZXojaw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Genetic polymorphisms in the region coding for GPX4 in 13 091 blood donors from the REDS RBC Omics. (A) Minor allele frequency for the most common SNPs in the region coding for GPX4 in 13 091 blood donors enrolled in REDS RBC Omics, and their association (–log10[P value]) to osmotic, oxidative, and storage hemolysis at storage day 42 (B). (C-D) Breakdown by demographics (sex, age, body mass index, ethnicity) for the top 2 common SNPs highlights the prevalence of these traits in female donors with higher body mass index and of African descent. (E-H) Breakdown of values for osmotic, oxidative, oxidized/reduced glutathione ratios (GSSG/GSH), and lactate levels as a function of rs73507255 (missense) SNP allele. (I) LDA of metabolite measurements in REDS index donors (n = 13 091) as a function of GPX4 rs73507255 alleles, unadjusted (x-axis), or adjusted by storage additive, donor sex, age, and body mass index. BMI, body mass index.
