Diagram of int22h-related rearrangements analysis through the DAHH. Wild type and Inv22 type I as examples. int22h-1 is located within intron 22 of F8. int22h-2 and int22h-3 are located within the 2 arms of a stem-loop structure. Inv22 type I represents the inversion of the fragment between int22h-1 and int22h-3. Red bands represent F8, blue bands represent the upstream sequence of int22h-2, green bands represent the upstream sequence of int22h-3, and gray bands represent the downstream sequence of int22h-2 and int22h-3.