Integrative gene prioritization. Autosomal genome-wide significant loci labeled by prioritized gene (x-axis) with shading for each line of evidence used in the bioinformatics-driven prioritization scheme (y-axis). Genes in bold were on the gold standard list (supplemental Table 7). The 7 lines of evidence evaluated were chosen to cover different mechanisms through which genetic variants contribute to disease risk, for example, regulatory changes vs protein perturbations. For VPS13D;DHRS3, F7;F10, and LINC02375;LINC02411, the genes had equal numbers of supporting lines of evidence. LINC00656 is also known as RP4-737E23.2. rs536995174 had 1 line of evidence each for SERPING1, SLC43A3, SLC43A1, F2, OR5AK4P, and LRRC55 and was excluded from this visualization. Genes with asterisks were selected for follow-up in a functional assay in zebrafish (Figure 3).
Figure 2.

Integrative gene prioritization. Autosomal genome-wide significant loci labeled by prioritized gene (x-axis) with shading for each line of evidence used in the bioinformatics-driven prioritization scheme (y-axis). Genes in bold were on the gold standard list (supplemental Table 7). The 7 lines of evidence evaluated were chosen to cover different mechanisms through which genetic variants contribute to disease risk, for example, regulatory changes vs protein perturbations. For VPS13D;DHRS3, F7;F10, and LINC02375;LINC02411, the genes had equal numbers of supporting lines of evidence. LINC00656 is also known as RP4-737E23.2. rs536995174 had 1 line of evidence each for SERPING1, SLC43A3, SLC43A1, F2, OR5AK4P, and LRRC55 and was excluded from this visualization. Genes with asterisks were selected for follow-up in a functional assay in zebrafish (Figure 3).

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