Cytokines, chemokines, and growth factor serum levels are associated with TL and blood cell counts. Some analytes were positively correlated with TL z score, implying that those patients with shorter telomeres present lower serum levels of such proteins. Cytopenia was also associated with several cytokines, chemokines, and growth factors, showing that marrow aplasia directly hampers the levels of these analytes. (A) Volcano plot showing data of Spearman correlations between the assessed cytokines, chemokines, and growth factors vs TL (z score transformed). Analytes shown in red are significantly associated with TL (P ≤ .050). (B) Heat map showing Spearman correlations between all analyzed analytes and blood cell counts. ∗P ≤ .05; ∗∗P ≤ .01; ∗∗∗P ≤ .001; ∗∗∗∗P ≤ .0001. HGF, hepatocyte growth factor; IFN, interferon; MCP, monocyte chemoattractant protein; M-CSF, macrophage colony-stimulating factor; MIP, macrophage inflammatory protein; MMP, matrix metalloproteinase; PDGF-BB, platelet-derived growth factor BB; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor.