ISTH-BAT scores and age in the Zimmerman Program. (A) Distribution of age among individuals from the United States/Canada and Ireland. The P value is the outcome of an independent t test. (B) The total ISTH-BAT score in the Zimmerman Program stratified for country. The P value is the outcome of independent t test. (C) Association between age and total ISTH-BAT score stratified for country. β and P value are outcomes of linear regression analysis. (D) Distribution of average scores on individual ISTH-BAT domains in the total adult cohort. The error bars depict standard deviations. CNS, central nervous system bleeding; GI, gastrointestinal.