Effect of blocking neutrophil surface molecules on the mechanisms of trogocytosis and ADCC. Trogocytosis (left) and ADCC (right) of neutrophils derived from healthy donors (n = 6) on the MOLP-8 myeloma cell line. (A) Effect of Fc receptor (CD16, CD32, and CD64) blockade on trogocytosis (left) and ADCC (right). (B) Effect of CD11b and/or CD18 integrin blockade on trogocytosis (left) and ADCC (right). (C) Effect of the don’t-eat-me signal molecule Signal Regulatory Protein Alpha (SIRPα) blockade on trogocytosis (left) and ADCC (right). Data represent mean ± SEM from 6 individual experiments. Each blocking condition was compared to the unblocked control by unpaired t test. ∗P < .05 and ∗∗P < .01. Whenever “basal death” is indicated, it means the death of MOLP-8 cells in basal culture conditions (without neutrophils and drug). The remaining conditions correspond to coculture of neutrophils and myeloma cells.
Figure 2.

Effect of blocking neutrophil surface molecules on the mechanisms of trogocytosis and ADCC. Trogocytosis (left) and ADCC (right) of neutrophils derived from healthy donors (n = 6) on the MOLP-8 myeloma cell line. (A) Effect of Fc receptor (CD16, CD32, and CD64) blockade on trogocytosis (left) and ADCC (right). (B) Effect of CD11b and/or CD18 integrin blockade on trogocytosis (left) and ADCC (right). (C) Effect of the don’t-eat-me signal molecule Signal Regulatory Protein Alpha (SIRPα) blockade on trogocytosis (left) and ADCC (right). Data represent mean ± SEM from 6 individual experiments. Each blocking condition was compared to the unblocked control by unpaired t test. ∗P < .05 and ∗∗P < .01. Whenever “basal death” is indicated, it means the death of MOLP-8 cells in basal culture conditions (without neutrophils and drug). The remaining conditions correspond to coculture of neutrophils and myeloma cells.

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