Intragenic deletions shape EBV genomes across disease landscapes. (A) Comprehensive overview of intragenic deletions (>50 bases) identified across diverse diseases. Each gray line represents the EBV genome of an individual patient. Filled bars denote complete deletions (with no remaining alleles), whereas open bars represent partial deletions (retaining some alleles). The affected viral components are indicated to the right of each EBV genome. A histogram summarizes the frequency of deletions in specific genomic regions, with blue and gray bars representing complete and partial deletions, respectively. The color codes for diseases (consistent with those used in Figure 1A) and EBV genome components are also indicated. (B) Distribution of deletion lengths across various disease categories, visualized with violin plots. Box plots within the violins illustrate interquartile ranges (the edges represent the 25th and 75th percentiles, whereas the inner bar indicates the median). ∗P < .01 (.00014 for CAEBV+DLBCL+ENKL+BL+HL vs IM+PTLD; .00197 for CAEBV+DLBCL+ENKL+BL+HL vs epithelial cell malignancies; .00181 for CAEBV+DLBCL+ENKL+BL+HL vs healthy donors). Other, other hematological diseases; epithelial, epithelial cell malignancies; healthy, healthy donors. (C) Disease-specific frequencies of deletions illustrating both overall deletions and those affecting specific viral components. (D-I) Zoomed-in views of specific EBV genomic regions highlighting deletion patterns. Numbers in these panels correspond to the individual miRNAs within the BARTmiR clusters. Color coding follows the same scheme as in panel A for consistency and clarity. BARTmiR, BART miRNAs; essential, essential genes for virion production; OriP, replication origin involved in latent infection; oriLyt, replication origin involved in lytic infection.
Figure 3.

Intragenic deletions shape EBV genomes across disease landscapes. (A) Comprehensive overview of intragenic deletions (>50 bases) identified across diverse diseases. Each gray line represents the EBV genome of an individual patient. Filled bars denote complete deletions (with no remaining alleles), whereas open bars represent partial deletions (retaining some alleles). The affected viral components are indicated to the right of each EBV genome. A histogram summarizes the frequency of deletions in specific genomic regions, with blue and gray bars representing complete and partial deletions, respectively. The color codes for diseases (consistent with those used in Figure 1A) and EBV genome components are also indicated. (B) Distribution of deletion lengths across various disease categories, visualized with violin plots. Box plots within the violins illustrate interquartile ranges (the edges represent the 25th and 75th percentiles, whereas the inner bar indicates the median). ∗P < .01 (.00014 for CAEBV+DLBCL+ENKL+BL+HL vs IM+PTLD; .00197 for CAEBV+DLBCL+ENKL+BL+HL vs epithelial cell malignancies; .00181 for CAEBV+DLBCL+ENKL+BL+HL vs healthy donors). Other, other hematological diseases; epithelial, epithelial cell malignancies; healthy, healthy donors. (C) Disease-specific frequencies of deletions illustrating both overall deletions and those affecting specific viral components. (D-I) Zoomed-in views of specific EBV genomic regions highlighting deletion patterns. Numbers in these panels correspond to the individual miRNAs within the BARTmiR clusters. Color coding follows the same scheme as in panel A for consistency and clarity. BARTmiR, BART miRNAs; essential, essential genes for virion production; OriP, replication origin involved in latent infection; oriLyt, replication origin involved in lytic infection.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal