Figure 1. Genomic landscape of EBV... | American Society of Hematology

$Genomic landscape of EBV strains and SNVs. (A) Concordance of viral genome sequencing across institutions. Eight cell lines were sequenced at ≥2 institutions (Jijoye and Namalwa were sequenced at 3 institutions, whereas the remaining 6 were sequenced at 2). Blue bars represent discordant SNVs, whereas the red box indicates a deletion. The numbers denote the total genomic differences observed between institutions. (B) Hierarchical clustering of 990 EBV genomes based on nucleotide variations. Alongside the hierarchical clustering, 2 PCs, countries of origin, associated diseases, assigned cluster numbers, EBV types (1/2), BALF2 mutations, and the presence of SVs are displayed. (C) Frequency of type 2 EBV genomes across different disease categories. B-cell–associated diseases exhibit a higher frequency of type 2 EBV compared with T/NK and epithelial cell (epi) diseases. (D) LD mapping across the EBV genome, with genome coordinates referenced to NC_007605.1. The W repeat region is masked in gray. (E) LD trend as a function of genomic distance. (F) Geometric distribution of single nucleotide variant frequency, the fraction of synonymous variants, and nucleotide alteration patterns. ∗P < .05. AITL, angioimmunoblastic T-cell lymphoma; GC, gastric carcinoma; HLH, hemophagocytic lymphohistiocytosis; LD, linkage disequilibrium; PC, principal component; T/NK-cell, T cell/natural killer cell.$

Figure 1.

Genomic landscape of EBV strains and SNVs. (A) Concordance of viral genome sequencing across institutions. Eight cell lines were sequenced at ≥2 institutions (Jijoye and Namalwa were sequenced at 3 institutions, whereas the remaining 6 were sequenced at 2). Blue bars represent discordant SNVs, whereas the red box indicates a deletion. The numbers denote the total genomic differences observed between institutions. (B) Hierarchical clustering of 990 EBV genomes based on nucleotide variations. Alongside the hierarchical clustering, 2 PCs, countries of origin, associated diseases, assigned cluster numbers, EBV types (1/2), BALF2 mutations, and the presence of SVs are displayed. (C) Frequency of type 2 EBV genomes across different disease categories. B-cell–associated diseases exhibit a higher frequency of type 2 EBV compared with T/NK and epithelial cell (epi) diseases. (D) LD mapping across the EBV genome, with genome coordinates referenced to NC_007605.1. The W repeat region is masked in gray. (E) LD trend as a function of genomic distance. (F) Geometric distribution of single nucleotide variant frequency, the fraction of synonymous variants, and nucleotide alteration patterns. ∗P < .05. AITL, angioimmunoblastic T-cell lymphoma; GC, gastric carcinoma; HLH, hemophagocytic lymphohistiocytosis; LD, linkage disequilibrium; PC, principal component; T/NK-cell, T cell/natural killer cell.

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