Immune microenvironment of cHL by EBV/HIV status. (A) Cell type proportions by EBV/HIV status estimated by CIBERSORTx. Color represents cell type. (B) Quantitative comparison of select immune cell types by EBV/HIV status. P values determined by Wilcoxon rank-sum test. (C) TCR Simpson clonality by EBV status. (D) TCR Simpson clonality by EBV/HIV status. P values determined by Wilcoxon rank-sum test. NK, natural killer.