Mutational profile of cHL. (A) TMB of cHL-associated genes by HIV status. (B) TMB of cHL-associated genes by EBV/HIV status. TMB is calculated as the number of total mutations per sample. Horizontal lines represent group median, and P values calculated by Wilcoxon rank-sum test. (C) Oncoplot of curated panel of cHL-associated genes. Oncoplot is grouped by EBV/HIV status, and colors represent type of mutation. N/A, not available.