Aged HSCs show low levels of DCFA8. In the absence of DCAF8, HSCs become apolar, which can be rescued by knockout of DOCK11. Polarity of HSCs is determined by the level of activity of the small RhoGTPase CDC42. See Figure 6 in the article by Xu et al that begins on page 1462.

Aged HSCs show low levels of DCFA8. In the absence of DCAF8, HSCs become apolar, which can be rescued by knockout of DOCK11. Polarity of HSCs is determined by the level of activity of the small RhoGTPase CDC42. See Figure 6 in the article by Xu et al that begins on page 1462.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal