Figure 4.
Common and rare HEA types. (A) Ancestral differences in frequencies of some common HEA types, which frequently elicit alloantibody formation. Heat map with the ancestry stratified frequencies of the common MNS, Rh, FY, and JK types in the unified set of 6679 DNA samples. Heat map colors range from yellow (0%) to deep blue (100%), showing HEA-type frequencies within each ancestry group. (B) Number of HFA− samples identified in the unified set of 6679 DNA samples with those identified by Sanquin and NYBC on the x- and y-axes, respectively. True negative, false negative in Sanquin, false positive and no-type in NYBC, no-type in Sanquin, no-type in NYBC, no-type in Sanquin and NYBC, and false negative in NYBC are showing in blue, red, green, orange, brown, gray, and magenta, respectively. (C) Number of patients typed negative for 16 HFA identified in the extended unified sample set. Bar plot shows phenotype and the count of negative typing results on the x- and y-axes, respectively. Typing results concordant with clinical type, array detected and confirmed, array detected and unconfirmed, false negative array types, and no-type results are shown in purple, blue, orange, yellow, and green, respectively. (D) Concordance between clinical and array-generated results for DNA samples harboring complex Rh genotypes. A graphical representation of 8 alleles of the RHD gene, in descending order: D+ (RHD∗01), weak D type 1 (RHD∗01W.1), weak D type 2 (RHD∗01W.2), weak D type 3 (RHD∗01W.3), D– (RHD∗01N.01), r'S type 1 (RHD∗03N.01), D pseudogene (RHD∗08N.01), and DEL1 (RHD∗01EL.01). Counts on the right show the number of alleles detected, confirmed by clinical type, and discordant in the extended unified sample set in black, green, and orange, respectively. AFR, African; AMR, Admixed American; EAS, East Asian; EUR, European; SAS, South Asian.

Common and rare HEA types. (A) Ancestral differences in frequencies of some common HEA types, which frequently elicit alloantibody formation. Heat map with the ancestry stratified frequencies of the common MNS, Rh, FY, and JK types in the unified set of 6679 DNA samples. Heat map colors range from yellow (0%) to deep blue (100%), showing HEA-type frequencies within each ancestry group. (B) Number of HFA− samples identified in the unified set of 6679 DNA samples with those identified by Sanquin and NYBC on the x- and y-axes, respectively. True negative, false negative in Sanquin, false positive and no-type in NYBC, no-type in Sanquin, no-type in NYBC, no-type in Sanquin and NYBC, and false negative in NYBC are showing in blue, red, green, orange, brown, gray, and magenta, respectively. (C) Number of patients typed negative for 16 HFA identified in the extended unified sample set. Bar plot shows phenotype and the count of negative typing results on the x- and y-axes, respectively. Typing results concordant with clinical type, array detected and confirmed, array detected and unconfirmed, false negative array types, and no-type results are shown in purple, blue, orange, yellow, and green, respectively. (D) Concordance between clinical and array-generated results for DNA samples harboring complex Rh genotypes. A graphical representation of 8 alleles of the RHD gene, in descending order: D+ (RHD∗01), weak D type 1 (RHD∗01W.1), weak D type 2 (RHD∗01W.2), weak D type 3 (RHD∗01W.3), D– (RHD∗01N.01), r'S type 1 (RHD∗03N.01), D pseudogene (RHD∗08N.01), and DEL1 (RHD∗01EL.01). Counts on the right show the number of alleles detected, confirmed by clinical type, and discordant in the extended unified sample set in black, green, and orange, respectively. AFR, African; AMR, Admixed American; EAS, East Asian; EUR, European; SAS, South Asian.

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