Array-generated typing for HEAs. (A) Comparison of clinical and UBDT_PC1 array-based HEA-typing density. In the graph, the presence of color represents a typing result (positive or negative), and the absence of color indicates a lack of a typing result. The graph is stratified according to the ancestry of the study participants, with a top and bottom panel for each ancestry group representing the density of clinical and array typing results, respectively. EUR, AFR, AMR, SAS, EAS, and OTH ancestries are shown. The HEA systems and relevant antigen types are indicated on top of the graph, and the typing density as a percentage of the total possible types is given on the right of the graph. (B) Concordance between clinical and array-generated HEA types. Bar plots showing the number of comparisons (y-axis) per HEA type (x-axis) with concordant results obtained by both Sanquin and NYBC in green and discordant results by both Sanquin and NYBC in blue, Sanquin only in orange and NYBC only in red. Ascending and descending bars represent the number of comparisons to positive clinical or negative clinical antigen types, respectively. Bar plots show the number of comparisons on a log scale. (C) HEA typing discordances. Heat map showing the cause of the discordance (columns) between clinical and array-generated types by HEA system (rows). The number of unique discordances per system and the number per cause of discordance are given on the right and top marginal bar plots, respectively. AFR, African; AMR, Admixed American; EAS, East Asian; EUR, European; OTH, other; SAS, South Asian.